AD Networks PPG Research Goals

Alzheimer's Disease

Alzheimer’s disease (AD) manifests as a devastating age-related progressive neurodegeneration and has become the third most common cause of mortality in the United States. The concomitant loss of cognitive function plagues more than 44 million individuals worldwide, marking AD as a looming public health crisis. To date, no approved therapies exist for the prevention or cure of AD, highlighting a crucial unmet clinical need. Through our proposed work, we aim to identify novel aspects of AD neuronal network dysfunction to nominate candidate avenues for therapeutic intervention through an in-depth understanding of the multifactorial inputs of cell type- and disease-specific biology.